![]() ![]() Although kappa analysis showed good agreement between the methods, with a weighted kappa of 0.681 (95% CI: 0.610–0.751) across all populations, the values for approximately half of the neonates at intermediate and high risk of hyperbilirubinemia (33/72) were underestimated by Roche TBiL.Ĭonclusion: Our results indicate that Roche TBiL and Ortho TSB measurements in the neonatal population are not consistent. A total of 207 neonates were eligible for evaluation of the agreement between the risk-grading methods. The average difference between the two methods was 0.1 ± 1.448 mg/dL. Roche TBiL and Ortho TSB measurements showed a good correlation ( r = 0.923 95% CI: 0.905–0.938). Results: We obtained 618 paired Roche TBiL and Ortho TSB results from 309 neonates. Weighted kappa analysis was used to evaluate the agreement between risk prediction by the two methods. For eligible newborns, the risk of developing severe hyperbilirubinemia was assessed using the Bhutani nomogram. The correlations and differences between two sets of results were determined using Passing–Bablok regression analysis and a Bland–Altman plot, respectively. Materials and Methods: Medical records of hospitalized neonates that underwent simultaneous Roche TBiL and Ortho TSB measurements were reviewed for eligibility selection and data collection. This study aimed to evaluate the accuracy and reliability of whole blood bilirubin measurements obtained using a Roche blood gas analyzer (Roche TBiL), with total serum bilirubin (TSB) measurements determined by the Ortho VITROS 4600 chemistry system (Ortho TSB) serving as a reference. ![]() 4Department of Clinical Laboratory, The Second Hospital of Tianjin Medical University, Tianjin, Chinaīackground: Accurate bilirubin measurements are essential for appropriate management of neonatal hyperbilirubinemia.3College of Medical Laboratory Science, Tianjin Medical University, Tianjin, China.2Department of Emergency Medicine, The Second Hospital of Tianjin Medical University, Tianjin, China. ![]() 1Department of Clinical Laboratory, The General Hospital of Tianjin Medical University, Tianjin, China.Qing Wang 1, Tianyi Zhang 2, Yuanxi Lin 2, Li Jiang 1, Wenlong Zhou 3 and Xiaolong Zong 4* ![]()
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